Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma

Three-dimensional cell culture methods are viable in vitro approaches that facilitate the examination of biological features cancer cells present in vivo. In this study, we demonstrate that hepatocellular carcinoma (HCC) cells in porous alginate scaffolds can generate organoid-like spheroids that mi...

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Bibliographic Details
Main Authors: Takai, Atsushi, Fako, Valerie, Dang, Hien, Forgues, Marshonna, Yu, Zhipeng, Budhu, Anuradha, Wang, Xin Wei
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754778/