SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly established. We demonstrate here that SCFFbxo22-KDM4A is a senescence-associated E3 ligase target...

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Bibliographic Details
Main Authors: Johmura, Yoshikazu, Sun, Jia, Kitagawa, Kyoko, Nakanishi, Keiko, Kuno, Toshiya, Naiki-Ito, Aya, Sawada, Yumi, Miyamoto, Tomomi, Okabe, Atsushi, Aburatani, Hiroyuki, Li, ShengFan, Miyoshi, Ichiro, Takahashi, Satoru, Kitagawa, Masatoshi, Nakanishi, Makoto
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754341/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754341/

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