Recent advances in understanding dengue
Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum bein...
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| Format: | Online |
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F1000Research
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754027/ |
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pubmed-47540272016-02-24 Recent advances in understanding dengue Yacoub, Sophie Mongkolsapaya, Juthathip Screaton, Gavin Review Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research. F1000Research 2016-01-19 /pmc/articles/PMC4754027/ /pubmed/26918159 http://dx.doi.org/10.12688/f1000research.6233.1 Text en Copyright: © 2016 Yacoub S et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yacoub, Sophie Mongkolsapaya, Juthathip Screaton, Gavin |
| spellingShingle |
Yacoub, Sophie Mongkolsapaya, Juthathip Screaton, Gavin Recent advances in understanding dengue |
| author_facet |
Yacoub, Sophie Mongkolsapaya, Juthathip Screaton, Gavin |
| author_sort |
Yacoub, Sophie |
| title |
Recent advances in understanding dengue |
| title_short |
Recent advances in understanding dengue |
| title_full |
Recent advances in understanding dengue |
| title_fullStr |
Recent advances in understanding dengue |
| title_full_unstemmed |
Recent advances in understanding dengue |
| title_sort |
recent advances in understanding dengue |
| description |
Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research. |
| publisher |
F1000Research |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754027/ |
| _version_ |
1613538731133763584 |