Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8

Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (>42 °C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity. In contrast, transient receptor potential melastatin 8 (TRPM8) is activated by low temperatures and menthol,...

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Bibliographic Details
Main Authors: Takaishi, Masayuki, Uchida, Kunitoshi, Suzuki, Yoshiro, Matsui, Hiroshi, Shimada, Tadashi, Fujita, Fumitaka, Tominaga, Makoto
Format: Online
Language:English
Published: Springer Japan 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752590/