Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam

In Vietnam, Plasmodium vivax (P. vivax) is the second most frequent human malaria parasite and a major obstacle to countrywide malaria elimination. Knowing the local parasite structure is useful for elimination efforts. Therefore, we analyzed, with a panel of 14 microsatellite markers, 234 P. vivax...

Full description

Bibliographic Details
Main Authors:	Hong, Nguyen Van, Delgado-Ratto, Christopher, Thanh, Pham Vinh, Van den Eede, Peter, Guetens, Pieter, Binh, Nguyen Thi Huong, Phuc, Bui Quang, Duong, Tran Thanh, Van Geertruyden, Jean Pierre, D’Alessandro, Umberto, Erhart, Annette, Rosanas-Urgell, Anna
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752448/

id	pubmed-4752448
recordtype	oai_dc
spelling	pubmed-47524482016-02-26 Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam Hong, Nguyen Van Delgado-Ratto, Christopher Thanh, Pham Vinh Van den Eede, Peter Guetens, Pieter Binh, Nguyen Thi Huong Phuc, Bui Quang Duong, Tran Thanh Van Geertruyden, Jean Pierre D’Alessandro, Umberto Erhart, Annette Rosanas-Urgell, Anna Research Article In Vietnam, Plasmodium vivax (P. vivax) is the second most frequent human malaria parasite and a major obstacle to countrywide malaria elimination. Knowing the local parasite structure is useful for elimination efforts. Therefore, we analyzed, with a panel of 14 microsatellite markers, 234 P. vivax mono infections in blood samples collected from 4 communities in central Vietnam. Genetic diversity in the population was moderate; a high occurrence of polyclonal infections and significant linkage disequilibrium were detected, suggesting inbreeding or recombination between highly related haplotypes. In addition, both genetic differentiation and population structure was low and only detected between communities at each side of the river. Those results suggest gene flow between study communities with the river defining a moderate geographical barrier. Future studies should determine how this genetic variation is maintained in an area of extremely low transmission. Public Library of Science 2016-02-12 /pmc/articles/PMC4752448/ /pubmed/26872387 http://dx.doi.org/10.1371/journal.pntd.0004434 Text en © 2016 Hong et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hong, Nguyen Van Delgado-Ratto, Christopher Thanh, Pham Vinh Van den Eede, Peter Guetens, Pieter Binh, Nguyen Thi Huong Phuc, Bui Quang Duong, Tran Thanh Van Geertruyden, Jean Pierre D’Alessandro, Umberto Erhart, Annette Rosanas-Urgell, Anna
spellingShingle	Hong, Nguyen Van Delgado-Ratto, Christopher Thanh, Pham Vinh Van den Eede, Peter Guetens, Pieter Binh, Nguyen Thi Huong Phuc, Bui Quang Duong, Tran Thanh Van Geertruyden, Jean Pierre D’Alessandro, Umberto Erhart, Annette Rosanas-Urgell, Anna Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
author_facet	Hong, Nguyen Van Delgado-Ratto, Christopher Thanh, Pham Vinh Van den Eede, Peter Guetens, Pieter Binh, Nguyen Thi Huong Phuc, Bui Quang Duong, Tran Thanh Van Geertruyden, Jean Pierre D’Alessandro, Umberto Erhart, Annette Rosanas-Urgell, Anna
author_sort	Hong, Nguyen Van
title	Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
title_short	Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
title_full	Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
title_fullStr	Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
title_full_unstemmed	Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam
title_sort	population genetics of plasmodium vivax in four rural communities in central vietnam
description	In Vietnam, Plasmodium vivax (P. vivax) is the second most frequent human malaria parasite and a major obstacle to countrywide malaria elimination. Knowing the local parasite structure is useful for elimination efforts. Therefore, we analyzed, with a panel of 14 microsatellite markers, 234 P. vivax mono infections in blood samples collected from 4 communities in central Vietnam. Genetic diversity in the population was moderate; a high occurrence of polyclonal infections and significant linkage disequilibrium were detected, suggesting inbreeding or recombination between highly related haplotypes. In addition, both genetic differentiation and population structure was low and only detected between communities at each side of the river. Those results suggest gene flow between study communities with the river defining a moderate geographical barrier. Future studies should determine how this genetic variation is maintained in an area of extremely low transmission.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752448/
_version_	1613538121985556480

Population Genetics of Plasmodium vivax in Four Rural Communities in Central Vietnam

Similar Items