CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells
Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3+ thymic Treg numbers in Ccr7−/− mice challenge this view, and the role of CCR7 in T...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751304/ |