Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura

This study aimed to investigate the dysfunctional ascending/descending pain pathways at the thalamic level in patients with migraine without aura (MWoA) using the effective connectivity analysis of the resting-state functional MRI. Twenty MWoA and 25 matched healthy controls participated in the rest...

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Main Authors:	Wang, Ting, Zhan, Wang, Chen, Qin, Chen, Ning, Zhang, Junpeng, Liu, Qi, He, Li, Zhang, Junran, Huang, Hua, Gong, Qiyong
Format:	Online
Language:	English
Published:	Lippincott Williams & Wilkins 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750503/

id	pubmed-4750503
recordtype	oai_dc
spelling	pubmed-47505032016-02-29 Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura Wang, Ting Zhan, Wang Chen, Qin Chen, Ning Zhang, Junpeng Liu, Qi He, Li Zhang, Junran Huang, Hua Gong, Qiyong Clinical Neuroscience This study aimed to investigate the dysfunctional ascending/descending pain pathways at the thalamic level in patients with migraine without aura (MWoA) using the effective connectivity analysis of the resting-state functional MRI. Twenty MWoA and 25 matched healthy controls participated in the resting-state functional MRI scans. The directional interactions between the posterior thalamus (PTH) and other brain regions were investigated using the Granger causality analysis and choosing bilateral PTH as two individual seeds. Pearson’s correlation analysis was carried out between the abnormal effective connectivity and the headache duration and pain intensity of MWoA. Compared with healthy controls, MWoA showed decreased inflows to the bilateral PTH from the ventromedial prefrontal cortex and the left precuneus/posterior cingulate cortex, decreased outflow from the left PTH to the ipsilateral dorsomedial prefrontal cortex, and increased inflow to the right PTH from the ipsilateral dorsolateral prefrontal cortex. In addition, the abnormal inflows to the right PTH from the ventromedial prefrontal cortex and the right dorsolateral prefrontal cortex correlated positively with the headache duration and pain intensity, respectively. The abnormal ascending/descending pain pathways between the thalamus and these cortical regions indicate a disrupted pain modulation in affective and sensory domains, which suggests a disequilibrium of pain inhibition and facilitation in MWoA. These findings may help to shed light on the pathophysiologic mechanisms of migraine. Lippincott Williams & Wilkins 2016-03-02 2016-02-17 /pmc/articles/PMC4750503/ /pubmed/26825347 http://dx.doi.org/10.1097/WNR.0000000000000529 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.http://creativecommons.org/licenses/by-nc/4.0/.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Ting Zhan, Wang Chen, Qin Chen, Ning Zhang, Junpeng Liu, Qi He, Li Zhang, Junran Huang, Hua Gong, Qiyong
spellingShingle	Wang, Ting Zhan, Wang Chen, Qin Chen, Ning Zhang, Junpeng Liu, Qi He, Li Zhang, Junran Huang, Hua Gong, Qiyong Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
author_facet	Wang, Ting Zhan, Wang Chen, Qin Chen, Ning Zhang, Junpeng Liu, Qi He, Li Zhang, Junran Huang, Hua Gong, Qiyong
author_sort	Wang, Ting
title	Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
title_short	Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
title_full	Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
title_fullStr	Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
title_full_unstemmed	Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
title_sort	altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura
description	This study aimed to investigate the dysfunctional ascending/descending pain pathways at the thalamic level in patients with migraine without aura (MWoA) using the effective connectivity analysis of the resting-state functional MRI. Twenty MWoA and 25 matched healthy controls participated in the resting-state functional MRI scans. The directional interactions between the posterior thalamus (PTH) and other brain regions were investigated using the Granger causality analysis and choosing bilateral PTH as two individual seeds. Pearson’s correlation analysis was carried out between the abnormal effective connectivity and the headache duration and pain intensity of MWoA. Compared with healthy controls, MWoA showed decreased inflows to the bilateral PTH from the ventromedial prefrontal cortex and the left precuneus/posterior cingulate cortex, decreased outflow from the left PTH to the ipsilateral dorsomedial prefrontal cortex, and increased inflow to the right PTH from the ipsilateral dorsolateral prefrontal cortex. In addition, the abnormal inflows to the right PTH from the ventromedial prefrontal cortex and the right dorsolateral prefrontal cortex correlated positively with the headache duration and pain intensity, respectively. The abnormal ascending/descending pain pathways between the thalamus and these cortical regions indicate a disrupted pain modulation in affective and sensory domains, which suggests a disequilibrium of pain inhibition and facilitation in MWoA. These findings may help to shed light on the pathophysiologic mechanisms of migraine.
publisher	Lippincott Williams & Wilkins
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750503/
_version_	1613537401515278336

Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura

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