Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes

Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes

Butyrophilins are proteins secreted during lactation and thought to influence immune function. Sarter et al. generated butyrophilin-2a2–deficient mice to show enhanced effector T cell responses, antitumor responses, and exacerbated EAE due to the impaired APC modulation of T cell immunity.

Bibliographic Details
Main Authors: Sarter, Kerstin, Leimgruber, Elisa, Gobet, Florian, Agrawal, Vishal, Dunand-Sauthier, Isabelle, Barras, Emmanuèle, Mastelic-Gavillet, Béatris, Kamath, Arun, Fontannaz, Paola, Guéry, Leslie, Duraes, Fernanda do Valle, Lippens, Carla, Ravn, Ulla, Santiago-Raber, Marie-Laure, Magistrelli, Giovanni, Fischer, Nicolas, Siegrist, Claire-Anne, Hugues, Stéphanie, Reith, Walter
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749920/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749920/

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