Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration

Intervertebral disk degeneration (IDD) is strongly associated with genetic predisposition and environmental susceptibility. Several studies been conducted to investigate the potential association between IDD and FokI polymorphism located in the gene encoding the vitamin D receptor (VDR), and inconsi...

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Main Authors:	Zhao, Jian, Yang, Mingyuan, Shao, Jie, Bai, Yushu, Li, Ming
Format:	Online
Language:	English
Published:	Elsevier 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747649/

id	pubmed-4747649
recordtype	oai_dc
spelling	pubmed-47476492016-03-01 Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration Zhao, Jian Yang, Mingyuan Shao, Jie Bai, Yushu Li, Ming Letter Intervertebral disk degeneration (IDD) is strongly associated with genetic predisposition and environmental susceptibility. Several studies been conducted to investigate the potential association between IDD and FokI polymorphism located in the gene encoding the vitamin D receptor (VDR), and inconsistent conclusions had been reached among different ethnic populations. In order to assess the association between the FokI polymorphism and the risk of IDD, we performed a comprehensive and systematic meta-analysis. Candidate articles were retrieved from PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and China Biology Medical (CBM) with strict inclusion criteria in January 2015. Among the 54 articles that were retrieved, only eight studies met the inclusion criteria. The pooled data analysis based on allele contrast, homozygote, heterozygote, dominant, and recessive models revealed no significant correlation between the FokI polymorphism and the risk of IDD. However, when stratified by ethnicity, significant associations were detected for Hispanics based on allele contrast (OR = 1.395, 95% CI = 1.059–1.836, P = 0.018), homozygote (OR = 1.849, 95% CI = 1.001–3.416, P = 0.049), heterozygote (OR = 1.254, 95% CI = 1.049–1.498, P = 0.013), and dominant (OR = 1.742, 95% CI = 1.174–2.583, P = 0.006) models, and for Asians using the dominant model (OR = 1.293, 95% CI = 1.025–1.632, P = 0.030), whereas there is no significant association detected for Caucasians. In conclusion, FokI polymorphism is not generally associated with IDD, but there is increased risk for IDD in Hispanics and Asians carrying FokI allele T. Elsevier 2015-12 2016-01-06 /pmc/articles/PMC4747649/ /pubmed/26772150 http://dx.doi.org/10.1016/j.gpb.2015.11.003 Text en © 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhao, Jian Yang, Mingyuan Shao, Jie Bai, Yushu Li, Ming
spellingShingle	Zhao, Jian Yang, Mingyuan Shao, Jie Bai, Yushu Li, Ming Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
author_facet	Zhao, Jian Yang, Mingyuan Shao, Jie Bai, Yushu Li, Ming
author_sort	Zhao, Jian
title	Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
title_short	Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
title_full	Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
title_fullStr	Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
title_full_unstemmed	Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
title_sort	association between vdr foki polymorphism and intervertebral disk degeneration
description	Intervertebral disk degeneration (IDD) is strongly associated with genetic predisposition and environmental susceptibility. Several studies been conducted to investigate the potential association between IDD and FokI polymorphism located in the gene encoding the vitamin D receptor (VDR), and inconsistent conclusions had been reached among different ethnic populations. In order to assess the association between the FokI polymorphism and the risk of IDD, we performed a comprehensive and systematic meta-analysis. Candidate articles were retrieved from PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and China Biology Medical (CBM) with strict inclusion criteria in January 2015. Among the 54 articles that were retrieved, only eight studies met the inclusion criteria. The pooled data analysis based on allele contrast, homozygote, heterozygote, dominant, and recessive models revealed no significant correlation between the FokI polymorphism and the risk of IDD. However, when stratified by ethnicity, significant associations were detected for Hispanics based on allele contrast (OR = 1.395, 95% CI = 1.059–1.836, P = 0.018), homozygote (OR = 1.849, 95% CI = 1.001–3.416, P = 0.049), heterozygote (OR = 1.254, 95% CI = 1.049–1.498, P = 0.013), and dominant (OR = 1.742, 95% CI = 1.174–2.583, P = 0.006) models, and for Asians using the dominant model (OR = 1.293, 95% CI = 1.025–1.632, P = 0.030), whereas there is no significant association detected for Caucasians. In conclusion, FokI polymorphism is not generally associated with IDD, but there is increased risk for IDD in Hispanics and Asians carrying FokI allele T.
publisher	Elsevier
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747649/
_version_	1613536336830005248

Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration

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