Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

About 85% of GISTs are associated with KIT and PDGFRα gene mutations, which predict response to tyrosine kinase inhibitors. Although the outcomes in patients affected by GIST have dramatically improved, tumor progression control still remains a challenge. The aim of this study is the genomic charact...

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Bibliographic Details
Main Authors: Saponara, Maristella, Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Ercolani, Giorgio, Del Gaudio, Massimo, Santini, Donatella, Pirini, Maria Giulia, Fiorentino, Michelangelo, Nannini, Margherita, Lolli, Cristian, Mandrioli, Anna, Gatto, Lidia, Brandi, Giovanni, Biasco, Guido, Pinna, Antonio Daniele, Pantaleo, Maria Abbondanza
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747222/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747222/

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