Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). The aim of this work was to compare the multidrug resistance (MDR) signature of IGHV mutated and unmutated CLL cells, identifying biochemical a...

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Bibliographic Details
Main Authors: Rigoni, Micol, Riganti, Chiara, Vitale, Candida, Griggio, Valentina, Campia, Ivana, Robino, Marta, Foglietta, Myriam, Castella, Barbara, Sciancalepore, Patrizia, Buondonno, Ilaria, Drandi, Daniela, Ladetto, Marco, Boccadoro, Mario, Massaia, Massimo, Coscia, Marta
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745766/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745766/

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