Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice

Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice

Prader-Willi syndrome (PWS) is a neurogenetic disorder caused by loss of paternally expressed genes on chromosome 15q11-q13. The PWS-critical region (PWScr) contains an array of non-protein coding IPW-A exons hosting intronic SNORD116 snoRNA genes. Deletion of PWScr is associated with PWS in humans...

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Main Authors: Rozhdestvensky, Timofey S., Robeck, Thomas, Galiveti, Chenna R., Raabe, Carsten A., Seeger, Birte, Wolters, Anna, Gubar, Leonid V., Brosius, Jürgen, Skryabin, Boris V.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742849/

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