Sorafenib-induced defective autophagy promotes cell death by necroptosis

Sorafenib-induced defective autophagy promotes cell death by necroptosis

Autophagy is one of the main cytoprotective mechanisms that cancer cells deploy to withstand the cytotoxic stress and survive the lethal damage induced by anti-cancer drugs. However, under specific conditions, autophagy may, directly or indirectly, induce cell death. In our study, treatment of the A...

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Bibliographic Details
Main Authors: Kharaziha, Pedram, Chioureas, Dimitris, Baltatzis, George, Fonseca, Pedro, Rodriguez, Patricia, Gogvadze, Vladimir, Lennartsson, Lena, Björklund, Ann-Charlotte, Zhivotovsky, Boris, Grandér, Dan, Egevad, Lars, Nilsson, Sten, Panaretakis, Theocharis
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741916/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741916/

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