The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

CDKN2A/p16INK4a is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16INK4a 5′UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16INK4a 5′UTR to...

Full description

Bibliographic Details
Main Authors: Bisio, Alessandra, Latorre, Elisa, Andreotti, Virginia, Bressac-de Paillerets, Brigitte, Harland, Mark, Scarra, Giovanna Bianchi, Ghiorzo, Paola, Spitale, Robert C., Provenzani, Alessandro, Inga, Alberto
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741874/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741874/

Similar Items