PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis. It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling pathways are aberrantly reactivated in pancreatic CSCs. Here, we examined the efficacy of combining NVP-LDE-225 (PI3K/...

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Bibliographic Details
Main Authors: Sharma, Narinder, Nanta, Rajesh, Sharma, Jay, Gunewardena, Sumedha, Singh, Karan P., Shankar, Sharmila, Srivastava, Rakesh K.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741658/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741658/

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