Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Pancreatic ductal adenocarcinoma (PDAC) cells utilize a novel non-canonical pathway of glutamine metabolism that is essential for tumor growth and redox balance. Inhibition of this metabolic pathway in PDAC can potentially synergize with therapies that increase intracellular reactive oxygen species...

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Bibliographic Details
Main Authors: Li, Doudou, Fu, Zhiqiang, Chen, Ruiwan, Zhao, Xiaohui, Zhou, Yu, Zeng, Bing, Yu, Min, Zhou, Quanbo, Lin, Qing, Gao, Wenchao, Ye, Huilin, Zhou, Jiajia, Li, Zhihua, Liu, Yimin, Chen, Rufu
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741594/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741594/

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