Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women

Background: Studies suggest that brain-derived neurotrophic factor (BDNF) exerts effects on the neuronal function of hippocampal neurons and increases hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, which causes depressive behaviors in rat or mouse. Here we focus on th...

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Main Authors:	Hui, Ling-yun, Wang, Ya-wen, Zhou, Fu-ling, Ma, Xian-cang, Yan, Run-zhi, Zhang, Lin, Wang, Quan-li, Yu, Xuewen
Format:	Online
Language:	English
Published:	Mary Ann Liebert, Inc. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741204/

id	pubmed-4741204
recordtype	oai_dc
spelling	pubmed-47412042016-02-09 Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women Hui, Ling-yun Wang, Ya-wen Zhou, Fu-ling Ma, Xian-cang Yan, Run-zhi Zhang, Lin Wang, Quan-li Yu, Xuewen Original Articles Background: Studies suggest that brain-derived neurotrophic factor (BDNF) exerts effects on the neuronal function of hippocampal neurons and increases hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, which causes depressive behaviors in rat or mouse. Here we focus on the change of serum MKP-1, BDNF, testosterone (T), and estradiol (E2) levels, in order to test the hypothesis that dysregulation of MKP-1, BDNF, T, and E2 are associated with depression in perimenopausal women. Mary Ann Liebert, Inc. 2016-01-01 /pmc/articles/PMC4741204/ /pubmed/26176177 http://dx.doi.org/10.1089/jwh.2015.5214 Text en © Ling-yun Hui, et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hui, Ling-yun Wang, Ya-wen Zhou, Fu-ling Ma, Xian-cang Yan, Run-zhi Zhang, Lin Wang, Quan-li Yu, Xuewen
spellingShingle	Hui, Ling-yun Wang, Ya-wen Zhou, Fu-ling Ma, Xian-cang Yan, Run-zhi Zhang, Lin Wang, Quan-li Yu, Xuewen Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
author_facet	Hui, Ling-yun Wang, Ya-wen Zhou, Fu-ling Ma, Xian-cang Yan, Run-zhi Zhang, Lin Wang, Quan-li Yu, Xuewen
author_sort	Hui, Ling-yun
title	Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
title_short	Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
title_full	Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
title_fullStr	Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
title_full_unstemmed	Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women
title_sort	association between mkp-1, bdnf, and gonadal hormones with depression on perimenopausal women
description	Background: Studies suggest that brain-derived neurotrophic factor (BDNF) exerts effects on the neuronal function of hippocampal neurons and increases hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, which causes depressive behaviors in rat or mouse. Here we focus on the change of serum MKP-1, BDNF, testosterone (T), and estradiol (E2) levels, in order to test the hypothesis that dysregulation of MKP-1, BDNF, T, and E2 are associated with depression in perimenopausal women.
publisher	Mary Ann Liebert, Inc.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741204/
_version_	1613533654671163392

Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women

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