Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.

Background: The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which...

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Main Authors:	Ma, Xiao, Chi, Yong-Hui, Niu, Ming, Zhu, Yun, Zhao, Yan-Ling, Chen, Zhe, Wang, Jia-Bo, Zhang, Cong-En, Li, Jian-Yu, Wang, Li-Fu, Gong, Man, Wei, Shi-Zhang, Chen, Chang, Zhang, Lu, Wu, Ming-Quan, Xiao, Xiao-He
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740759/

id	pubmed-4740759
recordtype	oai_dc
spelling	pubmed-47407592016-02-11 Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall. Ma, Xiao Chi, Yong-Hui Niu, Ming Zhu, Yun Zhao, Yan-Ling Chen, Zhe Wang, Jia-Bo Zhang, Cong-En Li, Jian-Yu Wang, Li-Fu Gong, Man Wei, Shi-Zhang Chen, Chang Zhang, Lu Wu, Ming-Quan Xiao, Xiao-He Pharmacology Background: The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which PLP affects ANIT-induced cholestasis in rats using a metabolomics approach. Frontiers Media S.A. 2016-02-04 /pmc/articles/PMC4740759/ /pubmed/26869930 http://dx.doi.org/10.3389/fphar.2016.00014 Text en Copyright © 2016 Ma, Chi, Niu, Zhu, Zhao, Chen, Wang, Zhang, Li, Wang, Gong, Wei, Chen, Zhang, Wu and Xiao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ma, Xiao Chi, Yong-Hui Niu, Ming Zhu, Yun Zhao, Yan-Ling Chen, Zhe Wang, Jia-Bo Zhang, Cong-En Li, Jian-Yu Wang, Li-Fu Gong, Man Wei, Shi-Zhang Chen, Chang Zhang, Lu Wu, Ming-Quan Xiao, Xiao-He
spellingShingle	Ma, Xiao Chi, Yong-Hui Niu, Ming Zhu, Yun Zhao, Yan-Ling Chen, Zhe Wang, Jia-Bo Zhang, Cong-En Li, Jian-Yu Wang, Li-Fu Gong, Man Wei, Shi-Zhang Chen, Chang Zhang, Lu Wu, Ming-Quan Xiao, Xiao-He Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
author_facet	Ma, Xiao Chi, Yong-Hui Niu, Ming Zhu, Yun Zhao, Yan-Ling Chen, Zhe Wang, Jia-Bo Zhang, Cong-En Li, Jian-Yu Wang, Li-Fu Gong, Man Wei, Shi-Zhang Chen, Chang Zhang, Lu Wu, Ming-Quan Xiao, Xiao-He
author_sort	Ma, Xiao
title	Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
title_short	Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
title_full	Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
title_fullStr	Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
title_full_unstemmed	Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.
title_sort	metabolomics coupled with multivariate data and pathway analysis on potential biomarkers in cholestasis and intervention effect of paeonia lactiflora pall.
description	Background: The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which PLP affects ANIT-induced cholestasis in rats using a metabolomics approach.
publisher	Frontiers Media S.A.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740759/
_version_	1613533445546311680

Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.

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