BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
•Blocking BET epigenetic readers with JQ1(+) mitigates neointimal proliferation in balloon-injured rat carotid arteries.•JQ1(+) or BRD4 knockdown inhibits vascular smooth muscle cell proliferation, migration, and PDGF receptor expression.•JQ1(+) prevents inflammatory dysfunction of vascular endothel...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740308/ |