RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

RNF126 is an E3 ubiquitin ligase. The deletion of RNF126 gene was observed in a wide range of human cancers and is correlated with improved disease-free and overall survival. These data highlights the clinical relevance of RNF126 in tumorigenesis and cancer therapy. However, the specific functions o...

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Bibliographic Details
Main Authors: Wang, Ying, Deng, Ou, Feng, Zhihui, Du, Zhanwen, Xiong, Xiahui, Lai, Jinzhi, Yang, Xiaosong, Xu, Mengyuan, Wang, Hongbing, Taylor, Derek, Yan, Chunhong, Chen, Ceshi, Difeo, Analisa, Ma, Zhefu, Zhang, Junran
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740281/

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