Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IAPP is innocuous under homeostatic conditions but i...

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Bibliographic Details
Main Authors: Rulifson, Ingrid C., Cao, Ping, Miao, Li, Kopecky, David, Huang, Linda, White, Ryan D., Samayoa, Kim, Gardner, Jonitha, Wu, Xiaosu, Chen, Kui, Tsuruda, Trace, Homann, Oliver, Baribault, Helene, Yamane, Harvey, Carlson, Tim, Wiltzius, Jed, Li, Yang
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739698/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739698/

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