Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

•Plasma NFL is a sensitive marker of neuronal injury•Plasma and CSF NFL concentrations were highly correlated•Plasma NFL is useful to detect active axonal injury in treated and untreated HIV

Bibliographic Details
Main Authors:	Gisslén, Magnus, Price, Richard W., Andreasson, Ulf, Norgren, Niklas, Nilsson, Staffan, Hagberg, Lars, Fuchs, Dietmar, Spudich, Serena, Blennow, Kaj, Zetterberg, Henrik
Format:	Online
Language:	English
Published:	Elsevier 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739412/

Similar Items

Corrigendum to: “Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: A cross-sectional study” [EBioMedicine 3 (216) 135–140]
by: Gisslén, Magnus, et al.
Published: (2016)

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury
by: Shahim, Pashtun, et al.
Published: (2016)

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection
by: Ahlgren, Erika, et al.
Published: (2016)

Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS
by: Bergman, Joakim, et al.
Published: (2016)

Cerebrospinal fluid viral breakthrough in two HIV-infected subjects on darunavir/ritonavir monotherapy
by: Gisslén, Magnus, et al.
Published: (2012)

Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
by: Peterson, Julia, et al.
Published: (2014)

Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection
by: Bremell, Daniel, et al.
Published: (2013)

Biomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients
by: Jessen Krut, Jan, et al.
Published: (2014)

Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia – case report
by: Andersson, Lars-Magnus, et al.
Published: (2006)

Blood–brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV
by: Anesten, Birgitta, et al.
Published: (2016)

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease
by: Mattsson, Niklas, et al.
Published: (2016)

Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
by: Andreasson, Ulf, et al.
Published: (2016)

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease
by: Piotr Lewczuk, et al.
Published: (2018-07-01)

Increased CSF Levels of Phosphorylated Neurofilament Heavy Protein following Bout in Amateur Boxers
by: Neselius, Sanna, et al.
Published: (2013)

Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection
by: Price, Richard W., et al.
Published: (2013)

Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy
by: Yilmaz, Aylin, et al.
Published: (2013)

Levels and Age Dependency of Neurofilament Light and Glial Fibrillary Acidic Protein in Healthy Individuals and Their Relation to the Brain Parenchymal Fraction
by: Vågberg, Mattias, et al.
Published: (2015)

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis
by: Irene Håkansson, et al.
Published: (2018-07-01)

Cerebrospinal Fluid Viral Load and Intrathecal Immune Activation in Individuals Infected with Different HIV-1 Genetic Subtypes
by: Abdulle, Sahra, et al.
Published: (2008)

The past and the future of Alzheimer's disease CSF biomarkers—a journey toward validated biochemical tests covering the whole spectrum of molecular events
by: Blennow, Kaj, et al.
Published: (2015)

Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected patients: a retrospective cross-sectional study
by: Jespersen, Sofie, et al.
Published: (2016)

The neurofilament derived-peptide NFL-TBS.40-63 enters in-vitro in human neural stem cells and increases their differentiation.
by: Kristell Barreau, et al.

Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease
by: Steinacker, Petra, et al.
Published: (2016)

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy
by: Rojas, Julio C., et al.
Published: (2016)

The definition of HIV-associated neurocognitive disorders: are we overestimating the real prevalence?
by: Gisslén, Magnus, et al.
Published: (2011)

Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
by: Landqvist Waldö, Maria, et al.
Published: (2013)

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
by: Rohrer, Jonathan D., et al.
Published: (2016)

Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection
by: Suh, Joome, et al.
Published: (2014)

Plasma tau levels in Alzheimer's disease
by: Zetterberg, Henrik, et al.
Published: (2013)

Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease
by: Öhrfelt, Annika, et al.
Published: (2016)

No diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSF
by: Cicognola, Claudia, et al.
Published: (2016)

Cerebrospinal fluid biomarkers for Alzheimer disease and subcortical axonal damage in 5,542 clinical samples
by: Skillbäck, Tobias, et al.
Published: (2013)

Injuries and home advantage in the NFL
by: Jones, Marshall B.
Published: (2016)

CNS reservoirs for HIV: implications for eradication
by: Hellmuth, Joanna, et al.
Published: (2015)

Cerebrospinal fluid HIV-1 RNA, intrathecal immunoactivation, and drug concentrations after treatment with a combination of saquinavir, nelfinavir, and two nucleoside analogues: the M61022 study
by: Yilmaz, Aylin, et al.
Published: (2006)

Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment
by: Edén, Arvid, et al.
Published: (2016)

Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from Patients with Alzheimer's Disease
by: Rosén, Christoffer, et al.
Published: (2014)

Structure-Function Analysis of the Glioma Targeting NFL-TBS.40-63 Peptide Corresponding to the Tubulin-Binding Site on the Light Neurofilament Subunit
by: Berges, Raphael, et al.
Published: (2012)

Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review
by: Leonardo Wiranata Soesilopranoto, et al.
Published: (2018-08-01)

Truth, Justice, and the NFL Way: Review: League of Denial: The NFL, Concussions, and the Battle for Truth
by: Stieg, Philip E.
Published: (2014)