Social and novel contexts modify hippocampal CA2 representations of space

The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentatio...

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Main Authors:	Alexander, Georgia M., Farris, Shannon, Pirone, Jason R., Zheng, Chenguang, Colgin, Laura L., Dudek, Serena M.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737730/

id	pubmed-4737730
recordtype	oai_dc
spelling	pubmed-47377302016-03-04 Social and novel contexts modify hippocampal CA2 representations of space Alexander, Georgia M. Farris, Shannon Pirone, Jason R. Zheng, Chenguang Colgin, Laura L. Dudek, Serena M. Article The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information. Nature Publishing Group 2016-01-25 /pmc/articles/PMC4737730/ /pubmed/26806606 http://dx.doi.org/10.1038/ncomms10300 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Alexander, Georgia M. Farris, Shannon Pirone, Jason R. Zheng, Chenguang Colgin, Laura L. Dudek, Serena M.
spellingShingle	Alexander, Georgia M. Farris, Shannon Pirone, Jason R. Zheng, Chenguang Colgin, Laura L. Dudek, Serena M. Social and novel contexts modify hippocampal CA2 representations of space
author_facet	Alexander, Georgia M. Farris, Shannon Pirone, Jason R. Zheng, Chenguang Colgin, Laura L. Dudek, Serena M.
author_sort	Alexander, Georgia M.
title	Social and novel contexts modify hippocampal CA2 representations of space
title_short	Social and novel contexts modify hippocampal CA2 representations of space
title_full	Social and novel contexts modify hippocampal CA2 representations of space
title_fullStr	Social and novel contexts modify hippocampal CA2 representations of space
title_full_unstemmed	Social and novel contexts modify hippocampal CA2 representations of space
title_sort	social and novel contexts modify hippocampal ca2 representations of space
description	The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737730/
_version_	1613532504467177472

Social and novel contexts modify hippocampal CA2 representations of space

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