Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics
The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefor...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737107/ |