Gastrointestinal Symptoms of Patients with Fabry Disease

In order to characterize gastrointestinal (GI) symptoms of 50 patients with Fabry disease (FD) (22 M; age range: 4–70 y; 35 adults and 15 children), validated questionnaires of GI symptoms were used to diagnose the functional gastrointestinal disorders (FGIDs) of the patients with GI symptoms (33/50...

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Main Authors:	Pensabene, Licia, Sestito, Simona, Nicoletti, Angela, Graziano, Francesca, Strisciuglio, Pietro, Concolino, Daniela
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736195/

id	pubmed-4736195
recordtype	oai_dc
spelling	pubmed-47361952016-02-15 Gastrointestinal Symptoms of Patients with Fabry Disease Pensabene, Licia Sestito, Simona Nicoletti, Angela Graziano, Francesca Strisciuglio, Pietro Concolino, Daniela Research Article In order to characterize gastrointestinal (GI) symptoms of 50 patients with Fabry disease (FD) (22 M; age range: 4–70 y; 35 adults and 15 children), validated questionnaires of GI symptoms were used to diagnose the functional gastrointestinal disorders (FGIDs) of the patients with GI symptoms (33/50 (66%); 25/35 adults and 8/15 children) according to Rome III criteria. In 16/25 of these adults and 2/8 of these children, the symptoms mimicked FGID. The adult subgroup included patients with unspecified functional bowel disorder (n = 9), functional bloating (n = 7), and IBS (n = 5), and the child subgroup included patients with abdominal migraine (n = 1) and IBS (n = 1). Among the 25 adults, 14 reported feeling full after a regular-size meal, and 12 complained of abdominal bloating/distension. All of the children with GI symptoms complained of low abdominal pain associated with changes in the form of the stool/improvements with defecation. In conclusion, according to Rome III criteria, the most frequent diagnoses of FGID among the adults with FD were unspecified functional bowel disorder, followed by functional bloating and IBS. The most frequent GI symptom in the children in our population was IBS-like abdominal pain, while the adults exhibited a full feeling following a regular-size meal and abdominal bloating/distension. Hindawi Publishing Corporation 2016 2015-12-31 /pmc/articles/PMC4736195/ /pubmed/26880903 http://dx.doi.org/10.1155/2016/9712831 Text en Copyright © 2016 Licia Pensabene et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pensabene, Licia Sestito, Simona Nicoletti, Angela Graziano, Francesca Strisciuglio, Pietro Concolino, Daniela
spellingShingle	Pensabene, Licia Sestito, Simona Nicoletti, Angela Graziano, Francesca Strisciuglio, Pietro Concolino, Daniela Gastrointestinal Symptoms of Patients with Fabry Disease
author_facet	Pensabene, Licia Sestito, Simona Nicoletti, Angela Graziano, Francesca Strisciuglio, Pietro Concolino, Daniela
author_sort	Pensabene, Licia
title	Gastrointestinal Symptoms of Patients with Fabry Disease
title_short	Gastrointestinal Symptoms of Patients with Fabry Disease
title_full	Gastrointestinal Symptoms of Patients with Fabry Disease
title_fullStr	Gastrointestinal Symptoms of Patients with Fabry Disease
title_full_unstemmed	Gastrointestinal Symptoms of Patients with Fabry Disease
title_sort	gastrointestinal symptoms of patients with fabry disease
description	In order to characterize gastrointestinal (GI) symptoms of 50 patients with Fabry disease (FD) (22 M; age range: 4–70 y; 35 adults and 15 children), validated questionnaires of GI symptoms were used to diagnose the functional gastrointestinal disorders (FGIDs) of the patients with GI symptoms (33/50 (66%); 25/35 adults and 8/15 children) according to Rome III criteria. In 16/25 of these adults and 2/8 of these children, the symptoms mimicked FGID. The adult subgroup included patients with unspecified functional bowel disorder (n = 9), functional bloating (n = 7), and IBS (n = 5), and the child subgroup included patients with abdominal migraine (n = 1) and IBS (n = 1). Among the 25 adults, 14 reported feeling full after a regular-size meal, and 12 complained of abdominal bloating/distension. All of the children with GI symptoms complained of low abdominal pain associated with changes in the form of the stool/improvements with defecation. In conclusion, according to Rome III criteria, the most frequent diagnoses of FGID among the adults with FD were unspecified functional bowel disorder, followed by functional bloating and IBS. The most frequent GI symptom in the children in our population was IBS-like abdominal pain, while the adults exhibited a full feeling following a regular-size meal and abdominal bloating/distension.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736195/
_version_	1613531793189765120

Gastrointestinal Symptoms of Patients with Fabry Disease

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