A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity

A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity

Single-nucleotide variation (SNV) is a crucial biomarker for drug resistance-related detection in cancer and bacterial infection. However, the unintended binding of DNA probes limits the specificity of SNV detection, and the need for redesigned sequences compromise the universality of SNV assay. Her...

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Bibliographic Details
Main Authors: Chen, Xueping, Zhou, Dandan, Shen, Huawei, Chen, Hui, Feng, Wenli, Xie, Guoming
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735751/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735751/

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