Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development
Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenc...
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| Format: | Online |
| Language: | English |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730126/ |
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pubmed-47301262016-02-11 Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development Kalcheim, Chaya Review Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenchyme and vice-versa are intimately associated with the segregation of homogeneous precursors into distinct fates. The neural crest and somites, progenitors of the peripheral nervous system and of skeletal tissues, respectively, beautifully illustrate the significance of EMT to the above processes. Ongoing studies progressively elucidate the gene networks underlying EMT in each system, highlighting the similarities and differences between them. Knowledge of the mechanistic logic of this normal ontogenetic process should provide important insights to the understanding of pathological conditions such as cancer metastasis, which shares some common molecular themes. MDPI 2015-12-23 /pmc/articles/PMC4730126/ /pubmed/26712793 http://dx.doi.org/10.3390/jcm5010001 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kalcheim, Chaya |
| spellingShingle |
Kalcheim, Chaya Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| author_facet |
Kalcheim, Chaya |
| author_sort |
Kalcheim, Chaya |
| title |
Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| title_short |
Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| title_full |
Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| title_fullStr |
Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| title_full_unstemmed |
Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development |
| title_sort |
epithelial–mesenchymal transitions during neural crest and somite development |
| description |
Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenchyme and vice-versa are intimately associated with the segregation of homogeneous precursors into distinct fates. The neural crest and somites, progenitors of the peripheral nervous system and of skeletal tissues, respectively, beautifully illustrate the significance of EMT to the above processes. Ongoing studies progressively elucidate the gene networks underlying EMT in each system, highlighting the similarities and differences between them. Knowledge of the mechanistic logic of this normal ontogenetic process should provide important insights to the understanding of pathological conditions such as cancer metastasis, which shares some common molecular themes. |
| publisher |
MDPI |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730126/ |
| _version_ |
1613529553158799360 |