Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found in MetS/T2DM, and oligomeric β-amyloid (Aβ) p...

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Bibliographic Details
Main Authors: Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729876/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729876/

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