Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the MCOLN1 gene, which encodes the lysosomal transient receptor potential ion channel mucolipin-1 (TRPML1). MLIV causes impaired motor and cognitive development, progressive loss of vision and gastric achlorhydria. Ho...

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Bibliographic Details
Main Authors: Grishchuk, Yulia, Peña, Karina A., Coblentz, Jessica, King, Victoria E., Humphrey, Daniel M., Wang, Shirley L., Kiselyov, Kirill I., Slaugenhaupt, Susan A.
Format: Online
Language:English
Published: The Company of Biologists 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728313/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728313/

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