X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study
X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep position of the body, because the surrounding tissues significantly attenuate the contrast of X-ray images. This study inv...
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| Format: | Online |
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726095/ |
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pubmed-47260952016-01-27 X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study Park, Hanwook Yeom, Eunseop Lee, Sang Joon Article X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep position of the body, because the surrounding tissues significantly attenuate the contrast of X-ray images. This study investigated the effect of surrounding tissues on X-ray beam attenuation by measuring the velocity fields of blood flows in deep vessels of a live rat. The decrease in image contrast was minimized by employing biocompatible CO2 microbubbles as tracer particles. The maximum measurable velocity of blood flows in the abdominal aorta of a rat model was found through comparative examination between the PIV measurement accuracy and the level of image contrast according to the input flow rate. Furthermore, the feasibility of using X-ray PIV to accurately measure in vivo blood flows was demonstrated by determining the velocity field of blood flows in the inferior vena cava of a rat. This study may serve as a reference in conducting in vivo X-ray PIV measurements of pulsatile blood flows in animal disease models and investigating hemodynamic characteristics and circulatory vascular diseases. Nature Publishing Group 2016-01-18 /pmc/articles/PMC4726095/ /pubmed/26777719 http://dx.doi.org/10.1038/srep19194 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Park, Hanwook Yeom, Eunseop Lee, Sang Joon |
| spellingShingle |
Park, Hanwook Yeom, Eunseop Lee, Sang Joon X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| author_facet |
Park, Hanwook Yeom, Eunseop Lee, Sang Joon |
| author_sort |
Park, Hanwook |
| title |
X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| title_short |
X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| title_full |
X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| title_fullStr |
X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| title_full_unstemmed |
X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study |
| title_sort |
x-ray piv measurement of blood flow in deep vessels of a rat: an in vivo feasibility study |
| description |
X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep position of the body, because the surrounding tissues significantly attenuate the contrast of X-ray images. This study investigated the effect of surrounding tissues on X-ray beam attenuation by measuring the velocity fields of blood flows in deep vessels of a live rat. The decrease in image contrast was minimized by employing biocompatible CO2 microbubbles as tracer particles. The maximum measurable velocity of blood flows in the abdominal aorta of a rat model was found through comparative examination between the PIV measurement accuracy and the level of image contrast according to the input flow rate. Furthermore, the feasibility of using X-ray PIV to accurately measure in vivo blood flows was demonstrated by determining the velocity field of blood flows in the inferior vena cava of a rat. This study may serve as a reference in conducting in vivo X-ray PIV measurements of pulsatile blood flows in animal disease models and investigating hemodynamic characteristics and circulatory vascular diseases. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726095/ |
| _version_ |
1613528080807100416 |