Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation

Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation

The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase re...

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Bibliographic Details
Main Authors: Kelkar, Madhura G., Senthilkumar, Kalimuthu, Jadhav, Smita, Gupta, Sudeep, Ahn, Beyong-Cheol, De, Abhijit
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726020/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726020/

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