A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism m...

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Main Authors:	Tomlinson, Jennifer H., Thompson, Gary S., Kalverda, Arnout P., Zhuravleva, Anastasia, O’Neill, Alex J.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725979/

id	pubmed-4725979
recordtype	oai_dc
spelling	pubmed-47259792016-01-28 A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance Tomlinson, Jennifer H. Thompson, Gary S. Kalverda, Arnout P. Zhuravleva, Anastasia O’Neill, Alex J. Article Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF-G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance. Nature Publishing Group 2016-01-19 /pmc/articles/PMC4725979/ /pubmed/26781961 http://dx.doi.org/10.1038/srep19524 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tomlinson, Jennifer H. Thompson, Gary S. Kalverda, Arnout P. Zhuravleva, Anastasia O’Neill, Alex J.
spellingShingle	Tomlinson, Jennifer H. Thompson, Gary S. Kalverda, Arnout P. Zhuravleva, Anastasia O’Neill, Alex J. A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
author_facet	Tomlinson, Jennifer H. Thompson, Gary S. Kalverda, Arnout P. Zhuravleva, Anastasia O’Neill, Alex J.
author_sort	Tomlinson, Jennifer H.
title	A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
title_short	A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
title_full	A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
title_fullStr	A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
title_full_unstemmed	A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
title_sort	target-protection mechanism of antibiotic resistance at atomic resolution: insights into fusb-type fusidic acid resistance
description	Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF-G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725979/
_version_	1613528015434678272

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

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