Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

MYBPC3 mutations cause hypertrophic cardiomyopathy, which is frequently associated with mitral valve (MV) pathology. We reasoned that increased MV size is caused by localized growth factors with paracrine effects. We used high-resolution echocardiography to compare Mybpc3-null, heterozygous, and wil...

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Bibliographic Details
Main Authors: Judge, Daniel P., Neamatalla, Hany, Norris, Russell A., Levine, Robert A., Butcher, Jonathan T., Vignier, Nicolas, Kang, Kevin H., Nguyen, Quangtung, Bruneval, Patrick, Perier, Marie-Cécile, Messas, Emmanuel, Jeunemaitre, Xavier, de Vlaming, Annemarieke, Markwald, Roger, Carrier, Lucie, Hagège, Albert A.
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725593/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725593/

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