Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

Multi-ciliated airway cells (MCACs) play a role in mucociliary clearance of the lung. However, the efficient induction of functional MCACs from human pluripotent stem cells has not yet been reported. Using carboxypeptidase M (CPM) as a surface marker of NKX2-1+-ventralized anterior foregut endoderm...

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Bibliographic Details
Main Authors: Konishi, Satoshi, Gotoh, Shimpei, Tateishi, Kazuhiro, Yamamoto, Yuki, Korogi, Yohei, Nagasaki, Tadao, Matsumoto, Hisako, Muro, Shigeo, Hirai, Toyohiro, Ito, Isao, Tsukita, Sachiko, Mishima, Michiaki
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720023/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720023/

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