Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently isomerization of the phosphorylated bonds. Interestingly, PIN1 is overexpressed in many types of malignancies including breast, pros...

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Bibliographic Details
Main Authors: Han, Hyeong-jun, Kwon, Nayoung, Choi, Min-A, Jung, Kyung Oh, Piao, Juan-Yu, Ngo, Hoang Kieu Chi, Kim, Su-Jung, Kim, Do-Hee, Chung, June-Key, Cha, Young-Nam, Youn, Hyewon, Choi, Bu Young, Min, Sang-Hyun, Surh, Young-Joon
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718546/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718546/

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