Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP

Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks. A recently reported SNP in prg‐1 (R345T/mutPRG‐1) affects ~5 million European and...

Full description

Bibliographic Details
Main Authors: Vogt, Johannes, Yang, Jenq‐Wei, Mobascher, Arian, Cheng, Jin, Li, Yunbo, Liu, Xingfeng, Baumgart, Jan, Thalman, Carine, Kirischuk, Sergei, Unichenko, Petr, Horta, Guilherme, Radyushkin, Konstantin, Stroh, Albrecht, Richers, Sebastian, Sahragard, Nassim, Distler, Ute, Tenzer, Stefan, Qiao, Lianyong, Lieb, Klaus, Tüscher, Oliver, Binder, Harald, Ferreiros, Nerea, Tegeder, Irmgard, Morris, Andrew J, Gropa, Sergiu, Nürnberg, Peter, Toliat, Mohammad R, Winterer, Georg, Luhmann, Heiko J, Huai, Jisen, Nitsch, Robert
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718157/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718157/

Similar Items