Dual use of GTP hydrolysis by elongation factor G on the ribosome

Elongation factor G (EF-G) is a GTPase that catalyzes tRNA and mRNA translocation during the elongation cycle of protein synthesis. The GTP-bound state of the factor on the ribosome has been studied mainly with non-hydrolyzable analogs of GTP, which led to controversial conclusions about the role of...

Full description

Bibliographic Details
Main Authors: Cunha, Carlos E., Belardinelli, Riccardo, Peske, Frank, Holtkamp, Wolf, Wintermeyer, Wolfgang, Rodnina, Marina V.
Format: Online
Language:English
Published: Taylor & Francis 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718068/