Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome

Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome

In Noonan Syndrome (NS) 30% to 50% of subjects show cognitive deficits of unknown etiology and with no known treatment. Here, we report that knock-in mice expressing either of two NS-associated Ptpn11 mutations show hippocampal-dependent spatial learning impairments and deficits in hippocampal long-...

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Bibliographic Details
Main Authors: Lee, Yong-Seok, Ehninger, Dan, Zhou, Miou, Oh, Jun-Young, Kang, Minkyung, Kwak, Chuljung, Ryu, Hyun-Hee, Butz, Delana, Araki, Toshiyuki, Cai, Ying, Balaji, J., Sano, Yoshitake, Nam, Christine I., Kim, Hyong Kyu, Kaang, Bong-Kiun, Burger, Corinna, Neel, Benjamin G., Silva, Alcino J.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716736/

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