Role of HLA Adaptation in HIV Evolution
Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus toward escape. The HLA class I molecules that are successful in mediating some degree of control over the virus are those that tend to present epitopes in conserved regions of the proteome, such as in p24 Ga...
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| Format: | Online |
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Frontiers Media S.A.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716577/ |
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pubmed-47165772016-01-29 Role of HLA Adaptation in HIV Evolution Kløverpris, Henrik N. Leslie, Alasdair Goulder, Philip Immunology Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus toward escape. The HLA class I molecules that are successful in mediating some degree of control over the virus are those that tend to present epitopes in conserved regions of the proteome, such as in p24 Gag, in which escape also comes at a significant cost to viral replicative capacity (VRC). In some instances, compensatory mutations can fully correct for the fitness cost of such an escape variant; in others, correction is only partial. The consequences of these events within the HIV-infected host, and at the population level following transmission of escape variants, are discussed. The accumulation of escape mutants in populations over the course of the epidemic already shows instances of protective HLA molecules losing their impact, and in certain cases, a modest decline in HIV virulence in association with population-level increase in mutants that reduce VRC. Frontiers Media S.A. 2016-01-18 /pmc/articles/PMC4716577/ /pubmed/26834742 http://dx.doi.org/10.3389/fimmu.2015.00665 Text en Copyright © 2016 Kløverpris, Leslie and Goulder. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kløverpris, Henrik N. Leslie, Alasdair Goulder, Philip |
| spellingShingle |
Kløverpris, Henrik N. Leslie, Alasdair Goulder, Philip Role of HLA Adaptation in HIV Evolution |
| author_facet |
Kløverpris, Henrik N. Leslie, Alasdair Goulder, Philip |
| author_sort |
Kløverpris, Henrik N. |
| title |
Role of HLA Adaptation in HIV Evolution |
| title_short |
Role of HLA Adaptation in HIV Evolution |
| title_full |
Role of HLA Adaptation in HIV Evolution |
| title_fullStr |
Role of HLA Adaptation in HIV Evolution |
| title_full_unstemmed |
Role of HLA Adaptation in HIV Evolution |
| title_sort |
role of hla adaptation in hiv evolution |
| description |
Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus toward escape. The HLA class I molecules that are successful in mediating some degree of control over the virus are those that tend to present epitopes in conserved regions of the proteome, such as in p24 Gag, in which escape also comes at a significant cost to viral replicative capacity (VRC). In some instances, compensatory mutations can fully correct for the fitness cost of such an escape variant; in others, correction is only partial. The consequences of these events within the HIV-infected host, and at the population level following transmission of escape variants, are discussed. The accumulation of escape mutants in populations over the course of the epidemic already shows instances of protective HLA molecules losing their impact, and in certain cases, a modest decline in HIV virulence in association with population-level increase in mutants that reduce VRC. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716577/ |
| _version_ |
1613525135313076224 |