Neurotropic virus infections as the cause of immediate and delayed neuropathology

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt th...

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Main Authors:	Ludlow, Martin, Kortekaas, Jeroen, Herden, Christiane, Hoffmann, Bernd, Tappe, Dennis, Trebst, Corinna, Griffin, Diane E., Brindle, Hannah E., Solomon, Tom, Brown, Alan S., van Riel, Debby, Wolthers, Katja C., Pajkrt, Dasja, Wohlsein, Peter, Martina, Byron E. E., Baumgärtner, Wolfgang, Verjans, Georges M., Osterhaus, Albert D. M. E.
Format:	Online
Language:	English
Published:	Springer Berlin Heidelberg 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713712/

id	pubmed-4713712
recordtype	oai_dc
spelling	pubmed-47137122016-01-22 Neurotropic virus infections as the cause of immediate and delayed neuropathology Ludlow, Martin Kortekaas, Jeroen Herden, Christiane Hoffmann, Bernd Tappe, Dennis Trebst, Corinna Griffin, Diane E. Brindle, Hannah E. Solomon, Tom Brown, Alan S. van Riel, Debby Wolthers, Katja C. Pajkrt, Dasja Wohlsein, Peter Martina, Byron E. E. Baumgärtner, Wolfgang Verjans, Georges M. Osterhaus, Albert D. M. E. Review A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens. Springer Berlin Heidelberg 2015-12-10 2016 /pmc/articles/PMC4713712/ /pubmed/26659576 http://dx.doi.org/10.1007/s00401-015-1511-3 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ludlow, Martin Kortekaas, Jeroen Herden, Christiane Hoffmann, Bernd Tappe, Dennis Trebst, Corinna Griffin, Diane E. Brindle, Hannah E. Solomon, Tom Brown, Alan S. van Riel, Debby Wolthers, Katja C. Pajkrt, Dasja Wohlsein, Peter Martina, Byron E. E. Baumgärtner, Wolfgang Verjans, Georges M. Osterhaus, Albert D. M. E.
spellingShingle	Ludlow, Martin Kortekaas, Jeroen Herden, Christiane Hoffmann, Bernd Tappe, Dennis Trebst, Corinna Griffin, Diane E. Brindle, Hannah E. Solomon, Tom Brown, Alan S. van Riel, Debby Wolthers, Katja C. Pajkrt, Dasja Wohlsein, Peter Martina, Byron E. E. Baumgärtner, Wolfgang Verjans, Georges M. Osterhaus, Albert D. M. E. Neurotropic virus infections as the cause of immediate and delayed neuropathology
author_facet	Ludlow, Martin Kortekaas, Jeroen Herden, Christiane Hoffmann, Bernd Tappe, Dennis Trebst, Corinna Griffin, Diane E. Brindle, Hannah E. Solomon, Tom Brown, Alan S. van Riel, Debby Wolthers, Katja C. Pajkrt, Dasja Wohlsein, Peter Martina, Byron E. E. Baumgärtner, Wolfgang Verjans, Georges M. Osterhaus, Albert D. M. E.
author_sort	Ludlow, Martin
title	Neurotropic virus infections as the cause of immediate and delayed neuropathology
title_short	Neurotropic virus infections as the cause of immediate and delayed neuropathology
title_full	Neurotropic virus infections as the cause of immediate and delayed neuropathology
title_fullStr	Neurotropic virus infections as the cause of immediate and delayed neuropathology
title_full_unstemmed	Neurotropic virus infections as the cause of immediate and delayed neuropathology
title_sort	neurotropic virus infections as the cause of immediate and delayed neuropathology
description	A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.
publisher	Springer Berlin Heidelberg
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713712/
_version_	1613524203996184576

Neurotropic virus infections as the cause of immediate and delayed neuropathology

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