Population Genetics of Plasmodium vivax in the Peruvian Amazon

We present the population genetics of malaria vivax parasites in a large area of the Peruvian Amazon. Our results showed that the parasite population had a predominant clonal propagation, reproducing themselves with identically or closely related parasites; therefore, the same genetic characteristic...

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Main Authors:	Delgado-Ratto, Christopher, Gamboa, Dionicia, Soto-Calle, Veronica E., Van den Eede, Peter, Torres, Eliana, Sánchez-Martínez, Luis, Contreras-Mancilla, Juan, Rosanas-Urgell, Anna, Rodriguez Ferrucci, Hugo, Llanos-Cuentas, Alejandro, Erhart, Annette, Van geertruyden, Jean-Pierre, D’Alessandro, Umberto
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713096/

id	pubmed-4713096
recordtype	oai_dc
spelling	pubmed-47130962016-01-26 Population Genetics of Plasmodium vivax in the Peruvian Amazon Delgado-Ratto, Christopher Gamboa, Dionicia Soto-Calle, Veronica E. Van den Eede, Peter Torres, Eliana Sánchez-Martínez, Luis Contreras-Mancilla, Juan Rosanas-Urgell, Anna Rodriguez Ferrucci, Hugo Llanos-Cuentas, Alejandro Erhart, Annette Van geertruyden, Jean-Pierre D’Alessandro, Umberto Research Article We present the population genetics of malaria vivax parasites in a large area of the Peruvian Amazon. Our results showed that the parasite population had a predominant clonal propagation, reproducing themselves with identically or closely related parasites; therefore, the same genetic characteristics are maintained in the offspring. The clonal propagation may favour the higher levels of genetic differentiation among the parasites from isolated areas compared to areas where human migration is common. The patterns of gene flow have been established, finding Iquitos city as a reservoir of parasite genetic variability. Moreover, a recent reduction of the parasite population was observed in areas where recent control activities were performed. This research provides a picture of the nature and dynamics of the parasite population which have a significant impact in the malaria epidemiology; therefore, this knowledge is crucial for the development of efficient control policies. Public Library of Science 2016-01-14 /pmc/articles/PMC4713096/ /pubmed/26766548 http://dx.doi.org/10.1371/journal.pntd.0004376 Text en © 2016 Delgado-Ratto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Delgado-Ratto, Christopher Gamboa, Dionicia Soto-Calle, Veronica E. Van den Eede, Peter Torres, Eliana Sánchez-Martínez, Luis Contreras-Mancilla, Juan Rosanas-Urgell, Anna Rodriguez Ferrucci, Hugo Llanos-Cuentas, Alejandro Erhart, Annette Van geertruyden, Jean-Pierre D’Alessandro, Umberto
spellingShingle	Delgado-Ratto, Christopher Gamboa, Dionicia Soto-Calle, Veronica E. Van den Eede, Peter Torres, Eliana Sánchez-Martínez, Luis Contreras-Mancilla, Juan Rosanas-Urgell, Anna Rodriguez Ferrucci, Hugo Llanos-Cuentas, Alejandro Erhart, Annette Van geertruyden, Jean-Pierre D’Alessandro, Umberto Population Genetics of Plasmodium vivax in the Peruvian Amazon
author_facet	Delgado-Ratto, Christopher Gamboa, Dionicia Soto-Calle, Veronica E. Van den Eede, Peter Torres, Eliana Sánchez-Martínez, Luis Contreras-Mancilla, Juan Rosanas-Urgell, Anna Rodriguez Ferrucci, Hugo Llanos-Cuentas, Alejandro Erhart, Annette Van geertruyden, Jean-Pierre D’Alessandro, Umberto
author_sort	Delgado-Ratto, Christopher
title	Population Genetics of Plasmodium vivax in the Peruvian Amazon
title_short	Population Genetics of Plasmodium vivax in the Peruvian Amazon
title_full	Population Genetics of Plasmodium vivax in the Peruvian Amazon
title_fullStr	Population Genetics of Plasmodium vivax in the Peruvian Amazon
title_full_unstemmed	Population Genetics of Plasmodium vivax in the Peruvian Amazon
title_sort	population genetics of plasmodium vivax in the peruvian amazon
description	We present the population genetics of malaria vivax parasites in a large area of the Peruvian Amazon. Our results showed that the parasite population had a predominant clonal propagation, reproducing themselves with identically or closely related parasites; therefore, the same genetic characteristics are maintained in the offspring. The clonal propagation may favour the higher levels of genetic differentiation among the parasites from isolated areas compared to areas where human migration is common. The patterns of gene flow have been established, finding Iquitos city as a reservoir of parasite genetic variability. Moreover, a recent reduction of the parasite population was observed in areas where recent control activities were performed. This research provides a picture of the nature and dynamics of the parasite population which have a significant impact in the malaria epidemiology; therefore, this knowledge is crucial for the development of efficient control policies.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713096/
_version_	1613524094962106368

Population Genetics of Plasmodium vivax in the Peruvian Amazon

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