Angiotensin-(1-7): new perspectives in atherosclerosis treatment
Angiotensin (Ang)-(1-7) is recognized as a new bioactive peptide in renin-angiotensin system (RAS). Ang-(1-7) is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-(1-7) played an important role in reducing smooth...
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| Format: | Online |
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Science Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712375/ |
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pubmed-47123752016-01-19 Angiotensin-(1-7): new perspectives in atherosclerosis treatment Zhang, Feng Liu, Jun Li, Su-Fang Song, Jun-Xian Ren, Jing-Yi Chen, Hong Review Angiotensin (Ang)-(1-7) is recognized as a new bioactive peptide in renin-angiotensin system (RAS). Ang-(1-7) is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-(1-7) played an important role in reducing smooth muscle cell proliferation and migration, improving endothelial function and regulating lipid metabolism, leading to inhibition of atherosclerotic lesions and increase of plaque stability. Although clinical application of Ang-(1-7) is restricted due to its pharmacokinetic properties, identification of stabilized compounds, including more stable analogues and specific delivery compounds, has enabled clinical application of Ang-(1-7). In this review, we discussed recent findings concerning the biological role of Ang-(1-7) and related mechanism during atherosclerosis development. In addition, we highlighted the perspective to develop therapeutic strategies using Ang-(1-7) to treat atherosclerosis. Science Press 2015-11 /pmc/articles/PMC4712375/ /pubmed/26788046 http://dx.doi.org/10.11909/j.issn.1671-5411.2015.06.014 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhang, Feng Liu, Jun Li, Su-Fang Song, Jun-Xian Ren, Jing-Yi Chen, Hong |
| spellingShingle |
Zhang, Feng Liu, Jun Li, Su-Fang Song, Jun-Xian Ren, Jing-Yi Chen, Hong Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| author_facet |
Zhang, Feng Liu, Jun Li, Su-Fang Song, Jun-Xian Ren, Jing-Yi Chen, Hong |
| author_sort |
Zhang, Feng |
| title |
Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| title_short |
Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| title_full |
Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| title_fullStr |
Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| title_full_unstemmed |
Angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| title_sort |
angiotensin-(1-7): new perspectives in atherosclerosis treatment |
| description |
Angiotensin (Ang)-(1-7) is recognized as a new bioactive peptide in renin-angiotensin system (RAS). Ang-(1-7) is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-(1-7) played an important role in reducing smooth muscle cell proliferation and migration, improving endothelial function and regulating lipid metabolism, leading to inhibition of atherosclerotic lesions and increase of plaque stability. Although clinical application of Ang-(1-7) is restricted due to its pharmacokinetic properties, identification of stabilized compounds, including more stable analogues and specific delivery compounds, has enabled clinical application of Ang-(1-7). In this review, we discussed recent findings concerning the biological role of Ang-(1-7) and related mechanism during atherosclerosis development. In addition, we highlighted the perspective to develop therapeutic strategies using Ang-(1-7) to treat atherosclerosis. |
| publisher |
Science Press |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712375/ |
| _version_ |
1613523885970423808 |