Structural dynamics of cisplatin binding to histidine in a protein
The platinum anti-cancer agents cisplatin and carboplatin bind to the histidine 15 residue in the model protein hen egg white lysozyme. By using temperatures either side of the protein glass transition state (∼180 K), several platinum binding modes are seen and show that not all these platinum modes...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
American Crystallographic Association
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711607/ |