Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior

Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central late...

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Main Authors:	Lin, Hui-Ching, Pan, Han-Chi, Lin, Sheng-Huang, Lo, Yu-Chun, Shen, Elise Ting-Hsin, Liao, Lun-De, Liao, Pei-Han, Chien, Yi-Wei, Liao, Kuei-Da, Jaw, Fu-Shan, Chu, Kai-Wen, Lai, Hsin-Yi, Chen, You-Yin
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710746/

id	pubmed-4710746
recordtype	oai_dc
spelling	pubmed-47107462016-01-20 Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior Lin, Hui-Ching Pan, Han-Chi Lin, Sheng-Huang Lo, Yu-Chun Shen, Elise Ting-Hsin Liao, Lun-De Liao, Pei-Han Chien, Yi-Wei Liao, Kuei-Da Jaw, Fu-Shan Chu, Kai-Wen Lai, Hsin-Yi Chen, You-Yin Neuroscience Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and α4-nicotinic acetylcholine receptor (α4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning. Frontiers Media S.A. 2016-01-13 /pmc/articles/PMC4710746/ /pubmed/26793069 http://dx.doi.org/10.3389/fncir.2015.00087 Text en Copyright © 2016 Lin, Pan, Lin, Lo, Shen, Liao, Liao, Chien, Liao, Jaw, Chu, Lai and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lin, Hui-Ching Pan, Han-Chi Lin, Sheng-Huang Lo, Yu-Chun Shen, Elise Ting-Hsin Liao, Lun-De Liao, Pei-Han Chien, Yi-Wei Liao, Kuei-Da Jaw, Fu-Shan Chu, Kai-Wen Lai, Hsin-Yi Chen, You-Yin
spellingShingle	Lin, Hui-Ching Pan, Han-Chi Lin, Sheng-Huang Lo, Yu-Chun Shen, Elise Ting-Hsin Liao, Lun-De Liao, Pei-Han Chien, Yi-Wei Liao, Kuei-Da Jaw, Fu-Shan Chu, Kai-Wen Lai, Hsin-Yi Chen, You-Yin Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
author_facet	Lin, Hui-Ching Pan, Han-Chi Lin, Sheng-Huang Lo, Yu-Chun Shen, Elise Ting-Hsin Liao, Lun-De Liao, Pei-Han Chien, Yi-Wei Liao, Kuei-Da Jaw, Fu-Shan Chu, Kai-Wen Lai, Hsin-Yi Chen, You-Yin
author_sort	Lin, Hui-Ching
title	Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
title_short	Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
title_full	Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
title_fullStr	Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
title_full_unstemmed	Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior
title_sort	central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior
description	Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and α4-nicotinic acetylcholine receptor (α4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning.
publisher	Frontiers Media S.A.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710746/
_version_	1613523386442448896

Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior

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