Arterial blood gas anomaly in canine hepatobiliary disease

Arterial blood gas anomaly in canine hepatobiliary disease

Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered h...

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Main Authors: KANEKO, Yasuyuki, TORISU, Shidow, KOBAYASHI, Takumi, MIZUTANI, Shinya, TSUZUKI, Nao, SONODA, Hiroko, IKEDA, Masahiro, NAGANOBU, Kiyokazu
Format: Online
Language:English
Published: The Japanese Society of Veterinary Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710720/
id pubmed-4710720
recordtype oai_dc
spelling pubmed-47107202016-01-14 Arterial blood gas anomaly in canine hepatobiliary disease KANEKO, Yasuyuki TORISU, Shidow KOBAYASHI, Takumi MIZUTANI, Shinya TSUZUKI, Nao SONODA, Hiroko IKEDA, Masahiro NAGANOBU, Kiyokazu Surgery Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. In addition, respiratory disorders account for 20% of perioperative fatalities in dogs. Therefore, in this study, we evaluated the respiratory status in dogs with hepatobiliary disease by arterial blood gas analysis. PaO2 and PaCO2 were measured. Alveolar-arterial oxygen difference (AaDO2), the indicator of gas exchange efficiency, was calculated. Compared to healthy dogs (control group), hepatobiliary disease dogs had significantly lower PaO2 and higher AaDO2. Hypoxemia (PaO2 of ≤80 mmHg) was observed in 28/71 dogs with hepatobiliary disease. AaDO2 was higher (≥30 mmHg) than the control group range (11.6 to 26.4 mmHg) in 32/71 hepatobiliary disease dogs. By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO2 and higher AaDO2 than in a control group. Dogs with chronic hepatitis also had significantly lower PaCO2. The present study shows that dogs with hepatobiliary disease have respiratory abnormalities more than healthy dogs. Preanesthetic or routine arterial blood gas analysis is likely beneficial to detect the respiratory abnormalities in dogs with hepatobiliary disease, especially extrahepatic biliary obstruction and chronic hepatitis. The Japanese Society of Veterinary Science 2015-08-08 2015-12 /pmc/articles/PMC4710720/ /pubmed/26256228 http://dx.doi.org/10.1292/jvms.15-0169 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author KANEKO, Yasuyuki
TORISU, Shidow
KOBAYASHI, Takumi
MIZUTANI, Shinya
TSUZUKI, Nao
SONODA, Hiroko
IKEDA, Masahiro
NAGANOBU, Kiyokazu
spellingShingle KANEKO, Yasuyuki
TORISU, Shidow
KOBAYASHI, Takumi
MIZUTANI, Shinya
TSUZUKI, Nao
SONODA, Hiroko
IKEDA, Masahiro
NAGANOBU, Kiyokazu
Arterial blood gas anomaly in canine hepatobiliary disease
author_facet KANEKO, Yasuyuki
TORISU, Shidow
KOBAYASHI, Takumi
MIZUTANI, Shinya
TSUZUKI, Nao
SONODA, Hiroko
IKEDA, Masahiro
NAGANOBU, Kiyokazu
author_sort KANEKO, Yasuyuki
title Arterial blood gas anomaly in canine hepatobiliary disease
title_short Arterial blood gas anomaly in canine hepatobiliary disease
title_full Arterial blood gas anomaly in canine hepatobiliary disease
title_fullStr Arterial blood gas anomaly in canine hepatobiliary disease
title_full_unstemmed Arterial blood gas anomaly in canine hepatobiliary disease
title_sort arterial blood gas anomaly in canine hepatobiliary disease
description Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. In addition, respiratory disorders account for 20% of perioperative fatalities in dogs. Therefore, in this study, we evaluated the respiratory status in dogs with hepatobiliary disease by arterial blood gas analysis. PaO2 and PaCO2 were measured. Alveolar-arterial oxygen difference (AaDO2), the indicator of gas exchange efficiency, was calculated. Compared to healthy dogs (control group), hepatobiliary disease dogs had significantly lower PaO2 and higher AaDO2. Hypoxemia (PaO2 of ≤80 mmHg) was observed in 28/71 dogs with hepatobiliary disease. AaDO2 was higher (≥30 mmHg) than the control group range (11.6 to 26.4 mmHg) in 32/71 hepatobiliary disease dogs. By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO2 and higher AaDO2 than in a control group. Dogs with chronic hepatitis also had significantly lower PaCO2. The present study shows that dogs with hepatobiliary disease have respiratory abnormalities more than healthy dogs. Preanesthetic or routine arterial blood gas analysis is likely beneficial to detect the respiratory abnormalities in dogs with hepatobiliary disease, especially extrahepatic biliary obstruction and chronic hepatitis.
publisher The Japanese Society of Veterinary Science
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710720/
_version_ 1613523373155942400

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