Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

Epidermal growth factor receptor kinase mutations drive oncogenesis, but the molecular mechanism of pathological signal initiation is poorly understood. Using high-resolution microscopy methods, the authors reveal that these kinase mutations induce structural changes in the receptor ectodomain that...

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Bibliographic Details
Main Authors: Valley, Christopher C., Arndt-Jovin, Donna J., Karedla, Narain, Steinkamp, Mara P., Chizhik, Alexey I., Hlavacek, William S., Wilson, Bridget S., Lidke, Keith A., Lidke, Diane S.
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710239/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710239/

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