Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12

Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12

Everts et al. use Batf3−/− mice to examine the role of Batf3-dependent CD8α+ and CD103+ DCs in Th2 immunity in response to helminth infection. Loss of Batf3-dependent DCs resulted in rapid control of normally chronic infection with Heligmosomoides polygyrus, whereas liver fibrosis was exacerbated wi...

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Bibliographic Details
Main Authors: Everts, Bart, Tussiwand, Roxane, Dreesen, Leentje, Fairfax, Keke C., Huang, Stanley Ching-Cheng, Smith, Amber M., O’Neill, Christina M., Lam, Wing Y., Edelson, Brian T., Urban, Joseph F., Murphy, Kenneth M., Pearce, Edward J.
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710198/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710198/

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