AB215. Variants in the SRD5A2 gene are associated with quality of semen

AB215. Variants in the SRD5A2 gene are associated with quality of semen

Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme converting testosterone into the more active metabolite, dihydrotestosterone (DHT). We aimed to investigate the association between the genetic variants of SRD5A2 (rs4952197, rs2268797...

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Main Authors: Zhao, Dan, Wu, Wei, Xu, Bin, Niu, Xiaobing, Cui, Hongxing, Zhang, Yi, Wang, Zengjun, Wang, Xinru
Format: Online
Language:English
Published: AME Publishing Company 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708336/
id pubmed-4708336
recordtype oai_dc
spelling pubmed-47083362016-01-26 AB215. Variants in the SRD5A2 gene are associated with quality of semen Zhao, Dan Wu, Wei Xu, Bin Niu, Xiaobing Cui, Hongxing Zhang, Yi Wang, Zengjun Wang, Xinru Abstract Publication Basic Research Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme converting testosterone into the more active metabolite, dihydrotestosterone (DHT). We aimed to investigate the association between the genetic variants of SRD5A2 (rs4952197, rs2268797, rs13395648, rs523349 and rs632148) and semen quality. Variant genotyping and semen analysis was performed in 708 males with definite idiopathic infertility by TaqMan SNP genotyping assays and computer-assisted semen analysis, respectively. It was found that the rs13395648 TC genotype was associated with a significantly lower semen volume compared with the TT genotype (P=0.016). The same trend was found between the combination of the TC and CC genotypes and the TT genotype (P=0.020). With regard to variant rs632148, subjects with the GC genotype had significantly lower sperm motility in comparison to those with the GG genotype (P=0.029). The sperm motility between the combination of the GC and CC genotypes and the GC genotype was also significantly different (P=0.033). These findings indicate that genetic variants in the SRD5A2 gene may be associated with semen quality. AME Publishing Company 2014-09 /pmc/articles/PMC4708336/ http://dx.doi.org/10.3978/j.issn.2223-4683.2014.s215 Text en 2014 Translational Andrology and Urology. All rights reserved.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhao, Dan
Wu, Wei
Xu, Bin
Niu, Xiaobing
Cui, Hongxing
Zhang, Yi
Wang, Zengjun
Wang, Xinru
spellingShingle Zhao, Dan
Wu, Wei
Xu, Bin
Niu, Xiaobing
Cui, Hongxing
Zhang, Yi
Wang, Zengjun
Wang, Xinru
AB215. Variants in the SRD5A2 gene are associated with quality of semen
author_facet Zhao, Dan
Wu, Wei
Xu, Bin
Niu, Xiaobing
Cui, Hongxing
Zhang, Yi
Wang, Zengjun
Wang, Xinru
author_sort Zhao, Dan
title AB215. Variants in the SRD5A2 gene are associated with quality of semen
title_short AB215. Variants in the SRD5A2 gene are associated with quality of semen
title_full AB215. Variants in the SRD5A2 gene are associated with quality of semen
title_fullStr AB215. Variants in the SRD5A2 gene are associated with quality of semen
title_full_unstemmed AB215. Variants in the SRD5A2 gene are associated with quality of semen
title_sort ab215. variants in the srd5a2 gene are associated with quality of semen
description Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme converting testosterone into the more active metabolite, dihydrotestosterone (DHT). We aimed to investigate the association between the genetic variants of SRD5A2 (rs4952197, rs2268797, rs13395648, rs523349 and rs632148) and semen quality. Variant genotyping and semen analysis was performed in 708 males with definite idiopathic infertility by TaqMan SNP genotyping assays and computer-assisted semen analysis, respectively. It was found that the rs13395648 TC genotype was associated with a significantly lower semen volume compared with the TT genotype (P=0.016). The same trend was found between the combination of the TC and CC genotypes and the TT genotype (P=0.020). With regard to variant rs632148, subjects with the GC genotype had significantly lower sperm motility in comparison to those with the GG genotype (P=0.029). The sperm motility between the combination of the GC and CC genotypes and the GC genotype was also significantly different (P=0.033). These findings indicate that genetic variants in the SRD5A2 gene may be associated with semen quality.
publisher AME Publishing Company
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708336/
_version_ 1613522375769325568

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