Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci

Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci

Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag−/− progenitor-B cells to determine whether Ig locus contra...

Full description

Bibliographic Details
Main Authors: Rother, Magdalena B., Palstra, Robert-Jan, Jhunjhunwala, Suchit, van Kester, Kevin A. M., van IJcken, Wilfred F. J., Hendriks, Rudi W., van Dongen, Jacques J. M., Murre, Cornelis, van Zelm, Menno C.
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705691/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705691/

Similar Items