Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans
Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited. Among these lesions, DNA interstrand crosslinks are among the more to...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704711/ |